Department V · The Knowledge Center
The Knowledge Center.
Technical notes, synthesis case studies, and supply-chain commentary from our team and our manufacturing partner.
Solid-Phase Peptide Synthesis at Research Scale: Choosing Resin, Coupling Reagents, and Cleavage Conditions
A practical decision framework for resin selection, activation chemistry, and cleavage cocktails at milligram-to-gram scale.
Read →Independent Verification: A Buyer's Guide to Reading Third-Party COAs
How to interpret an independent HPLC/MS report, what the numbers mean, and where discrepancies hide.
Read →Cold-Chain Logistics for Lyophilized Peptides: What Goes Wrong, and How to Detect It
Excursion risk, evidence of degradation, and the documentation that lets a buyer detect a compromised shipment.
Read →Synthesizing Hydrophobic Peptides: Solubility, Aggregation, and Purification Strategy
Handling aggregation-prone sequences from coupling through RP-HPLC purification.
Read →Disulfide-Bridge Peptides: Folding Conditions and Identity Confirmation
Oxidative folding strategy and confirming the correct disulfide connectivity by MS.
Read →Long Sequences (>40mer): When to Use Native Chemical Ligation
Where stepwise SPPS reaches its limit and ligation becomes the better route.
Read →The 2026 HHS Category 1 Reclassification: Implications for Compounding Pharmacies
A plain-language read of the reclassification and what it changes for compounding-pharmacy supply.
Read →Importing Peptide APIs: HTS Codes, FDA Holds, and the Documentation Trail
The customs and documentation realities of moving peptide material across the U.S. border.
Read →On the Difference Between a Certificate of Analysis and a Marketing Claim
Why a number on a chromatogram and a number in a brochure are not the same thing.
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